Players can even parlay multiple live bets together or mix and match live and pregame wagers as they see fit. These include point spreads, moneylines, totals, and derivatives. Bettors will find that many of the most popular pregame bets morph into an in-play form once the bell sounds. Put simply, in-play wagering is betting on a game already in progress. Traditionally, the first crack of the bat or first dribble on the hardwood hardly signifies the end of betting. Any Other Disadvantages Worth Knowing About?.